Question: What U.S. highway is known as the “Main Street of America” **and crosses 12 states, including Ohio?

Answer: U.S. Route 40. In 1926, Route 40 was constructed on top of the National Road, initially stretching from New Jersey to California. Route 40 enters the Buckeye State at Wheeling, traveling through Zanesville, Columbus, and Springfield before continuing westward to Indiana.